Psyllium contains a large amount of soluble dietary fiber, which helps create large soft stools that are easy to pass. It is effective at relieving both constipation and diarrhea, and also helps people achieve modest reductions in cholesterol, according to the U.S. National Institutes of Health (NIH). Few side effects are associated with psyllium.
Gastrointestinal Effects
The most common side effects associated with psyllium are intestinal gas, feelings of abdominal fullness, mild abdominal cramps, minor bloating and nausea. Reducing the amount of psyllium you take can help. Obstruction in the gastrointestinal tract has occurred, according to the NIH, and is most likely to occur in people with anatomic abnormalities or who have had a previous bowel surgery. Obstruction also may happen if psyllium is not mixed with enough water. Obstruction may cause severe abdominal pain, vomiting and difficulty swallowing, and requires immediate medical attention.
Allergic Reaction
Some people may experience a hypersensitive or allergic reaction to psyllium. Signs of an allergic reaction call for immediate medical attention and include a rash or hives, trouble breathing, tightness in the chest and facial or mouth swelling, as listed by Drugs.com. An allergic reaction to psyllium should be considered a medical emergency as it can lead to the shock reaction anaphylaxis, which can be life threatening. People most likely to experience a hypersensitive or allergic reaction include health care workers who have prepared psyllium solutions, and anyone allergic to English plantain pollen, grass pollen or melon.
Blood Sugar Reduction
Psyllium may reduce blood glucose levels, as explained by the NIH, so diabetic patients should monitor their blood sugar closely when using this supplement. An individual taking metformin or insulin for diabetes may need to reduce the medication dosage.



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