1. Get Plenty of Rest and Fluids
Since mononucleosis is a viral infection, there is no cure for the disease, and no specific treatment can effectively eliminate symptoms. To alleviate the symptoms, including the significant fatigue that accompanies the disease, get plenty of bed rest and maintain a high fluid intake. Expelling the virus through frequent urination will help you to feel better faster.
2. Use Antibiotics to Fight Secondary Infections
Mononucleosis increases your risk for developing infections of streptococcus bacteria, especially strep throat. Other infections that may develop include tonsillitis or sinus infections. Your doctor may prescribe antibiotics to preempt these complications. However, in most cases your doctor will prescribe antibiotics only if you begin to show symptoms of an ancillary bacterial infection. You can reduce any undesirable side effects associated with antibiotics by switching to different medications. Some patients experience allergic reactions to amoxicillin, erythromycin and other drugs. Ask your doctor to switch medication if you experience stomach upset, nausea or skin rashes after starting an antibiotic.
3. Treat Your Symptoms
You probably will develop a sore throat, so your doctor might prescribe a special medication to alleviate the pain. Headaches can be treated with over-the-counter painkillers, and most of the acute symptoms of mono will abate within a few weeks. If they persist, or seem unusually severe, ask your doctors what other options may be available to you.


