Monoamine oxidase inhibitors (MAOIs) are antidepressant medications that are specifically used to manage major depression. Major depression is a psychiatric condition in which people suffer from hopelessness, sadness, fatigue and difficulty sleeping. Other symptoms of this condition include a poor appetite, weight loss and crying spells. MAOIs manage these symptoms.
Phenelzine
Phenelzine, commonly sold as Nardil, increases chemicals in the brain to decrease depression symptoms. Drugs.com says phenelzine's less-serious side effects include constipation, an upset stomach, impotence, weakness and drowsiness. In some instances, phenelzine leads to trouble sleeping, decreased urination and difficulty having an orgasm. This drug's serious side effects include chest pain, a severe headache, fainting, a slow or fast heart rate, neck stiffness, vomiting and nausea. In some instances, phenelzine causes panic attacks, irritability, agitation, hostility and hyperactiveness. Notify a doctor when phenelzine leads to these side effects. Phenelzine is a tablet taken daily or as indicated.
Isocarboxazid
Isocarboxazid, commonly sold as Marplan, is another MAOI that elevates the amount of brain chemicals so that depression symptoms dramatically decline. Drugs.com says that isocarboxazid's less-concerning side effects include dizziness, shaking, tremors, dry mouth, constipation and nausea. This drug's serious side effects include chest pain, a fast or irregular heartbeat, yellowing of the skin or eyes, chest pain and rapid weight gain. Notify a doctor when isocarboxazid leads to these effects. Isocarboxazid is a tablet taken daily or as prescribed.
Selegiline
Selegiline, commonly sold as Zelapar or Eldepryl, is a monoamine oxidase type B inhibitor that specifically increases the amount of dopamine in the brain. MedlinePlus indicates that some of selegiline's less-serious side effects include nausea, fainting, vomiting, heartburn, constipation, muscle weakness or pain and a rash. In some instances, selegiline causes weakness, stomach pain and redness or mouth sores. Some of its serious side effects include chest pain, a severe headache, confusion, trouble breathing, hallucinations, neck stiffness and a fast or irregular heartbeat. Call a doctor when selegiline leads to these side effects. This medication is a tablet or capsule taken two times a day.
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