Motrin (ibuprofen) is a non-steroidal anti-inflammatory (NSAID) medication used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, back pain, arthritis, menstrual cramps or minor injury, reports Drugs.com. It is available both over the counter and by prescription. Motrin should not be used during pregnancy.
Abdominal Discomfort
Motrin may cause abdominal cramps or pain, bloating, flatulence (gas), nausea, constipation and diarrhea. Your physician may recommend that you take Motrin with food or an antacid to avoid stomach upset, states PDR Health. These side effects may diminish over time as your body adjusts to Motrin. Eating smaller meals more frequently and eating bland foods may help alleviate abdominal discomfort. If abdominal discomfort becomes severe, contact your health care professional.
Headache and Dizziness
You may experience headache and dizziness while taking Motrin. Use caution while driving or operating machinery until you know how this medication will affect you.
Skin Effects
Skin itching and rash may occur while taking Motrin. This effect may lessen over time as your body adjusts to Motrin. Consult your physician to determine if your rash is a side effect of Motrin or an unrelated harmless condition. An over-the-counter cream such as Cortaid may help abate itching and rash.
Bleeding
An uncommon side effect of ibuprofen is bleeding. Bleeding can occur anywhere in the body, but especially in the gastrointestinal tract. Be alert for tarry-looking stools or dark vomit that resembles used coffee grounds, which are both symptoms of gastrointestinal bleeding. Contact your health care provider if you experience signs and symptoms of bleeding prior to taking another dose of Motrin.



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