Collagen is a protein that occurs naturally in bones, connective tissues and skin. Collagen keeps skin looking youthful and also helps keep ligaments, tendons and joints healthy. Because collagen breaks down as people age, individuals may choose to supplement collagen orally or with injections. Facial injections rejuvenate skin appearance, and oral supplements may relieve pain and swelling of rheumatoid arthritis and osteoarthritis, according to Arthritis M.D. Supplementing with collagen has certain risks, although significant side effects are unlikely.
Food Sensitivity Reactions
Side effects associated with oral collagen supplements are uncommon and mainly related to food sensitivity. Most oral collagen supplements are derived from cow or chicken body parts, so people sensitive to these foods, or to gelatin, may have negative reactions to oral collagen. Arthritis M.D. notes that nausea was reported as a side effect in one study of oral collagen supplements. Supplements are not approved by the U.S. Food and Drug Administration as drugs are, and may be contaminated with other substances not listed in the ingredients. Consumers may experience a sensitivity reaction to one of those substances. People should only buy collagen supplements from a reputable manufacturer.
Allergic Reactions
Dermatologists and plastic surgeons most commonly administer collagen injections, but other physicians can legally do so as well. In some states, nurses and physician assistants can administer collagen injections under the supervision of a physician. About three percent of patients have an allergic reaction to collagen injections, according to the Mayo Clinic. People should have their skin tested to check for allergic reactions to cow or pig before having collagen injections. Allergic reaction effects can include tender bumps or skin ulcers that may take several months to disappear. Serious reactions can involve hives, difficulty breathing, low blood pressure and chest pain.
Injection Side Effects
People undergoing injected collagen treatment may experience temporary bruising, tenderness, pain and swelling at the affected area. The collagen may be visible temporarily and look like small white bumps, or it may move and create uneven texture and appearance. A patient prone to cold sores may develop cold sores after collagen lip treatment. A small risk of infection, abscess, scarring or skin necrosis also is possible.
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