Doryx (doxycycline hyclate) is a prescription tetracyclic antibiotic used to treat certain types of bacterial infections that may affect specific body regions, including the eyes, bladder or intestines. This medication is typically administered orally (tablet) as prescribed by your doctor and works by preventing the growth of bacteria within your body. Discuss Doryx antibiotic side effects with your pharmacist before you begin treatment with this medication.
Stomach Upset
While receiving treatment with Doryx, you can experience stomach-related side effects, warn health officials at Daily Med, an informational prescription drug website established by the U.S. National Library of Medicine. Nausea or vomiting can occur, which can be uncomfortable for certain patients. You can also experience diarrhea in conjunction with genital or anal itching, or abdominal cramping or bloating. These side effects can lead to a decrease in your normal appetite.
On rare occasions, patients using oral Doryx have reported inflammation or skin ulcerations within the throat or esophagus. Such side effects can be painful and may cause difficulty swallowing, which can contribute to appetite loss. Eating a small snack or drinking a glass of milk immediately before taking a dose of Doryx can help limit the occurrence of these stomach upset side effects in certain patients, advises Daily Med.
Angioedema
The use of Doryx can cause angioedema to develop in certain patients as a side effect of treatment. Angioedema is characterized by swelling that occurs beneath the skin. Symptoms can include chest pain or swelling of the mouth, face, legs or arms, explains Drugs.com, a peer-reviewed drug information website for consumers. These side effects can be uncomfortable and can lead to sensations of mild pain near the affected body region. Talk with your doctor if you experience chest pain, as this side effect can be indicative of heart-related medical complications, such as heart attack.
Increased Sunlight Sensitivity
You can experience increased skin sensitivity to sunlight while taking Doryx, reports PDR Health, a health information website established by the publishers of the Physicians' Desk Reference. These side effects can lead to the appearance of red, irritated patches across skin that has been exposed to sunlight. The affected skin region may develop a burning or itching sensation, or may be tender to the touch. While using this medication, avoid unnecessary sun exposure and be sure to protect your skin with clothing or sun screen if you choose to spend time outdoors. Severe skin reactions, such as hives or skin welts, should be immediately reported to your doctor, as these side effects may indicate that you are having an allergic reaction to this medication.
Bulging Forehead
Abnormal bulging of the forehead has been reported in certain patients (particularly infants and children) taking Doryx, reports Daily Med. You may notice that your child's head appears unusually swollen or enlarged, a side effect that resolves once treatment with this medication ends.
Tooth Discoloration
Long-term use of Doryx can cause permanent tooth discoloration in patients under the age of eight. Health educators at Drugs advise that infants and children younger than eight years of age avoid using this medication due to this side effect.



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