Magnesium is an essential mineral that the body uses for metabolic reactions, energy production, RNA and DNA synthesis, bone and cell structure, and regulation of other nutrients. Side effects of magnesium supplements are rare but can occur when extremely high doses are consumed. Excess can cause toxicity in individuals who have impaired kidney function and are unable to excrete excess magnesium.
Medication Interactions
The Linus Pauling Institute (LPI) at Oregon State University and the University of Maryland Medical Center (UMMC) say magnesium could interact with heart medications, antibiotics, anti-malaria and chemotherapy drugs, steroids and diuretics. The LPI recommends taking magnesium and certain medications two hours apart to avoid malabsorption of the medication and negative interactions.
Intestinal Discomfort
The UMMC says magnesium in high doses could cause nausea, vomiting, and an upset stomach. Diarrhea is a common side effect of milk of magnesia, a type of magnesium used as a laxative.
Additional Side Effects
Additional side effects of magnesium supplementation are commonly associated with magnesium toxicity and high-dose supplementation. Side effects can include lethargy, confusion, abnormal heart rhythms, muscle weakness, poor calcium absorption, difficulty breathing, decreased blood pressure and loss of appetite. In severe and rare cases of magnesium toxicity, cardiac arrest, coma and death have occurred according to the LPI and UMMC.
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