Comtrex is an over-the-counter combination analgesic/antihistamine/decongestant medication used for treating symptoms of the common cold, hay fever or flu. According to PDR Health, Comtrex treats runny nose, sneezing, stuffy nose, fever, sinus headaches and mild aches. Avoid drinking alcohol while taking Comtrex, since it contains acetaminophen which may put you at risk for liver damage if mixed with alcohol.
Common Side Effects
Common Comtrex side effects include dizziness, drowsiness, headache and blurred vision. Use caution while driving or completing activities that may be dangerous until you know how Comtrex will affect you. Nausea, stomach pain, constipation and loss of appetite can occur while taking Comtrex. Taking your medication with food may help alleviate gastrointestinal side effects. You may experience rash and insomnia, and some children may experience restlessness and excitability.
Serious Side Effects
Serious Comtrex side effects include fast, uneven heartbeat, dizziness, nervousness, restlessness, hallucinations, confusion, and unusual thoughts and behaviors. These symptoms should be brought to the attention of your health care provider immediately. Some users may experience an increase in blood pressure, which may be dangerous. Signs of high blood pressure include headache, blurry vision, fatigue, visual changes and chest pain. Take your blood pressure at home (if possible) in the event you experience these signs. Serious gastrointestinal effects include nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), states Drugs.com. Seek emergency medical attention if any of these symptoms occur while taking Comtrex.
Allergic Reaction
You may experience an allergic reaction to Comtrex. According to PDR Health, you should not use this medicine if you have had an allergic reaction to any cough, cold or pain medicine, or if you have taken a MAO inhibitor such as Nardil, Marplan, Eldepryl or Parnate within the past 14 days. Symptoms of an allergic reaction include rash and hives, wheezing, difficulty breathing, or swelling of the lips, tongue or throat. Seek emergency medical attention if you experience an allergic reaction to Comtrex.



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