Estrace (estradiol) is a prescription vaginal cream used to alleviate symptoms of vaginal dryness or irritation in menopausal women. This medication is administered into the vagina with an applicator and should be used only as prescribed by a doctor. Estrace contains estradiol, a form of the female sex hormone estrogen. Discuss Estrace vaginal cream side effects with a gynecologist before beginning treatment.
Breast Swelling
While using Estrace vaginal cream, women can experience unusual swelling of the breast tissue, according to Drugs.com, a drug information website that provides peer-reviewed information to consumers. Breast tissue swelling can cause women to experience a sensation of fullness within the breasts. Certain women might find that the affected breast tissue is tender or painful to the touch. These side effects of Estrace vaginal cream are typically temporary and will subside with continued use.
Skin Changes
Women using Estrace can experience skin changes as a side effect of treatment. Skin discoloration conditions, such as melasma, can develop in certain women and might persist even after treatment has ended, warn health officials with Daily Med, a drug information website supported by the National Institutes of Health. Certain women can also develop pus-filled skin lesions across the face. These skin lesions can appear red and might itch. Contact a doctor if these skin-related side effects of Estrace vaginal cream worsen.
Stomach Upset
Treatment with this medication can lead to stomach-related side effects in certain women. These stomach upset symptoms can include nausea, heartburn, vomiting or decreased appetite, explains MedlinePlus, a medical information resource established by the U.S. National Library of Medicine.
Vaginal Irritation or Bleeding
Use of Estrace vaginal cream can cause vaginal side effects to develop in certain women, explains MedlinePlus. Women can experience unusual vaginal swelling, irritation, itching or burning, which may be accompanied by abnormal discharge. Irregular vaginal bleeding may also develop in certain women but typically resolves with continued use of this medication. Talk with a doctor if any of these vaginal side effects emerge as these symptoms can be indicative of alternate vaginal infections or medical complications.
Mood Changes
Unusual mood changes, such as depression, irritability or nervousness, can arise in women during treatment with Estrace vaginal cream, according to Daily Med. These side effects should be discussed with a doctor.
Sexual Difficulties
Women using Estrace vaginal cream can develop sexual difficulties as a side effect of treatment, according to Drugs.com. These sexual side effects can include decreased sexual drive or difficulty becoming aroused during sexual stimulation. Talk with a doctor if these side effects are bothersome or interfere with intimate relationships.
