An antipyretic is any medication that can help to reduce a fever. There are both prescription-level and over-the-counter (OTC) medications that are classified as antipyretics. Typical OTC antipyretics, which are the most commonly used fever reducers, include acetylsalicylic acid (aspirin), acetaminophen, ibuprofen and naproxen sodium. Although the Mayo Clinic recommends against giving aspirin to a child with a fever, since this may cause a condition known as Reye's syndrome that can be fatal. Acetaminophen has no reported common side effects.
Nausea
Among the most common serious potential side effects of an antipyretic is nausea or queasiness. This side effect usually occurs with such medications as aspirin and ibuprofen. With ibuprofen, this form of stomach upset may also cause vomiting. These are serious problems if they occur with ibuprofen, but are classified as non-serious and temporary by Drugs.com with aspirin.
Pain
Naproxen sodium is marketed under such names as Aleve as an OTC medication. It can induce several common serious side effects, including headaches, and chest and stomach pain. Ibuprofen, marketed as Advil and Motrin, among other brand names, can cause stomach, chest and throat pain. These all are categorized as serious common side effects, and the Mayo Clinic recommends consulting a physician if you experience them.
Breathing Problems
Both naproxen sodium and ibuprofen can also cause problems in the respiratory system, including breathing difficulties such as shortness of breath, chest tightness and wheezing. There may also be a rattling noise when breathing. Breathing may be difficult either at rest or during exertion. Contact your doctor immediately if you experience any of these breathing problems.
Skin Problems
Ibuprofen and naproxen sodium also may cause various problems on the skin, including itching, skin eruptions and discolored patches of skin. These may be flat and large, and usually are purple or blue. Ibuprofen may cause itchy skin that turns pale, or a rash that includes either raised or flat lesions.



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