Histamine is a naturally-occurring organic compound, and is found in humans and animals. It can be found in cells throughout the body, the digestive tract, and in the brain acting as a neurotransmitter. Typically, histamine is known as the agent responsible in allergic reactions, insect bites, and hay fever. On the other hand, it also serves other more desirable effects on the body including wakefulness and increased orgasm potential.
Allergic Reactions
Histamine plays an essential role in the body's protection against foreign invaders. It acts as an alarm bell for the immune system when foreign toxins have entered the body. Mast cells and white blood cells, called basophils, release histamine where the foreign element is, and a resulting itch and inflammation is the common result. Common examples of this occur with mosquito bites, food allergies, and dust and pollen in the air. At healthy levels, histamine alerts the body not to come into contact with certain types of insects, plants, and foods, but excessive histamine levels can make people miserable, such as those who experience hay fever. Duquesne University states that histamine plays a dual role in the immune system by facilitating the flow of white bloods cells to the site of the toxin, as well as inducing fluid secretion in order for the body to eliminate the toxin faster.
Wakefulness
The role of histamine has been identified in recent research regarding its essential role in sleep regulation and wakefulness. It is most active during wakefulness and least active during restorative and dream sleep. It is also activated at high levels during the transition from sleep to waking up in the morning. Because histamine is so effective at promoting wakefulness, histamine blockers are some of the most common ingredients found in over-the-counter sleeping aids. Dr. Jerome Siegel and associates at the University of California-Los Angeles, found that histamine is an essential neurotransmitter in the process of waking, explaining the powerful effect that antihistamines have in sedation.
Orgasm Regulation
Histamine has also been found to play a significant role in sexual health due to its role in a completed orgasm. During sexual intercourse, mast cells collect in the male and female genitals, and in order for orgasm to complete, the mast cells trigger a massive release of histamine. Women who have significant difficulty reaching orgasm have been found to have very low blood plasma levels of histamine. In addition, both men and women treated with histamine supplements have reported increases in the quantity and quality of orgasms. Histamine plays such a vital role in male orgasm that antihistamines are sometimes prescribed by doctors for the treatment of pre-ejaculatory syndrome. The Society of Obstetricians and Gynaecologists of Canada state that cyproheptadine, a serotonin and histamine antagonist is an effective medical intervention in treating male sexual dysfunction.
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