1. Symmetrical Joint Pain
Rheumatoid arthritis typically affects the joints symmetrically. For example, if the thumb of the right hand becomes affected, the thumb of the left hand will often follow suit within a week to a year. Rheumatoid arthritis most often affects the hands and wrists and the feet and ankles. The condition may emerge suddenly, but more often develops slowly and insidiously, most commonly between the ages of 25 and 50. Rheumatoid arthritis affects women two to three times more often than men.
2. Ulnar Deviation and Soft Tissue Swelling
As the soft tissue swelling affects the connective tissue of the hands, the fingers often become slightly deviated toward the ulnar bone. The hands and fingers begin to become skewed toward the lateral side, a phenomenon known as "ulnar deviation." The knuckles, especially those closest to the palm of the hand, can become tender and swollen, as can the base of the toes.
Rheumatoid arthritis involves the soft tissues surrounding joints -- the connective tissue, the synovial membranes and the joint capsules. These tissues become thickened, and can give the joint a swollen, bulbous appearance. These joints can sometimes become acutely inflamed, feeling hot to the touch and looking red in appearance. Sufferers feel pain when using the affected joints, experience stiffness upon waking in the morning that takes several hours to clear up, and have discomfort when pressure is put on the affected joint.
3. Rheumatoid nodules
One-third or more of people with rheumatoid arthritis display "rheumatoid nodules." These nodules are like tiny pebbles that can be felt, or in many cases plainly seen, overlying the affected joint (such as a knuckle). Rheumatoid nodules result from an inflammation of the connective tissue that, over time, leads to an accumulation of scar tissue that replaces and displaces the functional soft tissues.
4. Joint Pain with Fever
Since rheumatoid arthritis is a condition that involves auto-immune inflammation, it may be accompanied by symptoms that typify an infection or immunologic activity. People with rheumatoid arthritis often experience fevers, generalized malaise and fatigue. A vague, "unwell" feeling is common, as is the need to take an afternoon nap and a feeling of exhaustion after physical activity. In some of the more severe cases, swelling of the lymph nodes and inflammation of the eyes may occur.
