What Are the Dangers of Yohimbe?

What Are the Dangers of Yohimbe?
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Yohimbe is an herbal supplement derived from an African evergreen tree. It has stimulant properties and is sometimes promoted as an herbal remedy for erectile dysfunction due to its ability to improve blood flow throughout the body. In addition to its extensive side effect profile, yohimbe may cause dangerous interactions with other herbs and medicines. Understanding the dangers of yohimbe can help prevent negative reactions associated with the supplement.

Side Effects

Yohimbe may cause a wide range of side effects, including kidney failure, seizures and heart rhythm abnormalities. Because it can cause relaxation of the uterus, do not take yohimbe if you are pregnant or may become pregnant. Yohimbe can cause toxic effects in babies and young children, so avoid using it if you are currently nursing.
Cardiovascular side effects are among yohimbe's most serious risks. It can cause both a rise and fall in blood pressure, as well as rapid heartbeat and arrhythmia. Symptoms of cardiovascular effects may include chest pain, severe headache and shortness of breath.
Like other stimulants, yohimbe may cause overstimulation of the central nervous system, leading to feeling jittery, irritable, dizzy and anxious. In people with pre-existing mental illness, yohimbe may trigger serious symptoms like mania, panic attacks or psychosis.
To reduce the risk for severe side effects, start with the lowest effective dose, and avoid taking yohimbe with other herbs or medications.

Interactions

Yohimbe can cause unexpected and potentially life-threatening interactions with many common medications. According to the National Institutes of Health, yohimbe inhibits the cytochrome liver enzyme, which can change the way many medications affect the body. Possible interactions include alcohol, opiates, tricyclic antidepressants, benzodiazepines and stimulants.
Yohimbe may also be dangerous when taken with other herbs and supplements. Herbs with stimulant properties--such as guarana, yerba mate or Sida cordifolia--can cause a dangerous rise in heart rate and blood pressure when taken with yohimbe, which is also a stimulant.

Dose and Purity

Because herbs and supplements are not closely regulated by the FDA, products containing yohimbe may contain unreliable doses of active compounds. The risk of contamination with heavy metals, pesticides and other toxic substances is also a concern. According to the Mayo Clinic, several "herbal Viagra" products containing yohimbe were removed from the market after they were found to contain prescription medications.
To reduce the risk of contamination, buy trusted brands that bear the "U.S. Pharmacopeia" seal of approval. Choose supplements that are standardized to contain a specific amount of active compounds, and ask your doctor before adding yohimbe to your supplement regimen.

References

Article reviewed by Roman Tsivkin Last updated on: May 18, 2010

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