The skin inflammation you're experiencing from Retin-A is simply a local reaction to the active ingredient of tretinoin. The Mayo Clinic explains that tretinoin is a prescription retinoid used for a number of different skin problems, including acne, fine lines and wrinkles, age spots and even stretch marks. However, creams containing this ingredient can actually trigger skin irritation, which can lead to inflammation and swelling. It often develops soon after application, but should subside with time and use.
Symptoms
The skin inflammation is often accompanied by other symptoms. It isn't uncommon to experience the sensations of stinging or burning as well as redness, drying and flaking of the skin from regular use, according to the Mayo Clinic. Given time, your skin can grow accustomed to the medication, and the local reaction may lessen in intensity and severity. It can take upward of three weeks for irritation to subside.
Dosage
The inflammation may be an indication that the current dosage is too strong for your skin or that you're applying too much medication at one time. Proper use requires only a light covering along affected or problematic areas, advises the Mayo Clinic.
Usage
The inflammation may also be a sign that the time between doses is too short. Instead of applying each day prior to bedtime, which is normally suggested, your skin may require one to three days in between applications. Always follow the instructions offered by your doctor or dermatologist.
Precautions
While using tretinoin, it's also important to avoid applying skin care products containing alcohol, salicylic acid, resorcinol, sulfur or benzoyl peroxide. These products can dry and peel the skin, causing added irritation and subsequent inflammation. Avoid soaps, cleansers, cosmetics, shaving creams and aftershaves that are too abrasive on the skin. Your doctor can recommend products and ingredients most appropriate for your skin and skin sensitivity. Sunscreens are often suggested during the use of Retin-A, as this medication can lead to UV sensitivity, maintains MedLine Plus.
Warning
If inflammation doesn't subside, or it's accompanied by blistering or crusting of the skin, stop use and contact your doctor immediately. You may require a change in medication or an adjustment in dosage. Further use may exacerbate the irritation and inflammation of your skin.



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