Rebif, or interferon beta-1a, controls the return of symptoms in multiple sclerosis. The National Multiple Sclerosis Society explains that MS affects the central nervous system, causing the brain and spinal cord to become inflamed and often leaving the patient disabled. Rebif does not cure MS and may not work for everyone, according to MS LifeLines.
Availability
RxList states Rebif comes in pre-filled syringes in doses of 8.8 mcg, 22 mcg and 44 mcg. The initial dosing starts low and gradually increases over five weeks before reaching a maintenance dose. This medication has been approved by the U.S. Food and Drug Administration since 2002, according to Drugs.com.
Use
Rebif is given in an injectable form, states Drugs.com. Patients should not self-administer this medication without proper instruction. Rotate Rebif injections to include the upper arm, abdomen or buttocks and do not give injections in an area that is bruised, irritated or infected. This medication should be refrigerated but not frozen. Patients should allow Rebif to warm to room temperature prior to injecting the serum. If Rebif freezes or is left in direct sunlight or heat, throw the product away.
Side Effects
Allergic reaction to Rebif requires immediate emergency assistance. Symptoms of allergic reaction include trouble breathing; hives; and swelling of the lips, throat or tongue. Other serious side effects of Rebif, according to Drugs.com, include depression, suicidal behavior, bruising, bleeding, seizures, numbness to extremities, painful urination, pain and swelling at injection site, flu-like symptoms and yellowing of the skin or eyes. Less serious side effects consist of headache, dizziness, abdominal pain and runny or stuffy nose.
Medication Interactions
Other medications can affect the way Rebif works. Drugs.com points out Rebif can harm the liver and if taken with other products, chances of liver damage increases. Patients should avoid using the following while taking Rebif: acetaminophen, cancer medications, tuberculosis medications, hormone or birth control pills, methotrexate, certain arthritis medications, antibiotics, HIV/AIDS medications, cholesterol lowering medications, anti-hypertensives such as ACE inhibitors, non-steroidal anti-inflammatory drugs and seizure medications.
Warnings
Drugs.com encourages patients to notify a health care provider of the following conditions prior to taking Rebif: liver disease, thyroid disorder, seizure disorders, depression, suicidal behavior and heart disease such as chest pain, congestive heart failure or abnormal heart rhythms. Pregnant patients should avoid the use of this medication due to known harmful effects to the fetus. Patients should discuss discontinuing the use of Rebif with the prescribing health care provider if symptoms of depression become evident.
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