Progesterone is a hormone produced in females and that can also be taken as a supplement. The American Pregnancy Association states that progesterone is produced by the ovarian follicle and also by the placenta. It helps to maintain the uterus and prepare for pregnancy. According to MayoClinic.com, for women who are not able to produce adequate amounts of progesterone, a pill called progestin can be taken as a supplement. Increased levels of progesterone can cause diverse side effects, such as mental depression, constipation, fatigue and headaches.
Mental Depression
MayoClinic.com states that an increased progesterone level during pregnancy can be associated with negative emotions like mental depression. Progesterone has a negative effect on the central nervous system of the body. When a pregnant women takes a progesterone supplement like the progestin pill, it can lead to mood swings.
Headaches and Constipation
MayoClinic.com reports that progesterone causes relaxation of smooth muscles such as those in the intestines. This reduces the time it takes food to pass through the intestines and increases the build up of waste. These decreased bowel contractions can lead to constipation, which also produces abdominal pain and cramping.
Smooth muscles can also be seen in blood vessels, which conduct the flow of blood throughout the body. Progesterone intake during pregnancy can cause increased blood flow to the brain and severe headaches.
Fatigue
Since progesterone can have a negative effect on the central nervous system, the MayoClinic.com reports that in high levels, it can cause drowsiness and fatigue. Women taking progesterone supplements during pregnancy can experience an unusual level of tiredness.


