Benadryl, also known as diphenhydramine, is a medication in a class of drugs known as antihistamines. Benadryl is used in the treatment of sneezing, runny nose, itching, watery eyes, hives, rashes and the common cold, according to Drugs.com. It may also be used in the treatment of insomnia, coughing, Parkinson's disease and motion sickness. There are some side effects of Benadryl in children that parents and caregivers should be aware of.
Drowsiness
Benadryl can cause drowsiness in children. Children may become more sleepy and tired than usual. Parents and caregivers should never give Benadryl or any other sedatives to infants under 1 year of age for sleep, according to AskDrSears.com. Although Benadryl is more likely to cause drowsiness, some children may react by becoming more awake, alert and restless.
Headache
Children may experience headache while taking Benadryl. If headache becomes bothersome, a pediatrician should be notified regarding the use of an over-the-counter pain reliever, such as children's acetaminophen, for the relief of headache pain and discomfort.
Nausea
Nausea may occur in children taking Benadryl. Taking this medication with food or milk may help diminish nausea. Children should avoid foods that are spicy, greasy and high in fat if they are experiencing nausea. Nausea that leads to vomiting should be reported to a pediatrician. Children can become dehydrated easily, which can be dangerous. In some cases, severe nausea and vomiting may be a sign of an allergic reaction to Benadryl.
Severe Reaction
Some children may experience a severe reaction to Benadryl. Symptoms can include difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives, according to Drugs.com. Parents should seek emergency medical attention if these symptoms occur.



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