Much research has been conducted on the effectiveness of St. John's wort in treating mental illnesses such as depression. In fact, it is proven to be nearly as effective as certain antidepressants in treating mild to moderate depression, according to the National Institutes of Health. It is generally safe and well-tolerated over periods of one to three months. The National Institutes of Health reports that 1 percent to 3 percent of people taking St. John's wort experience side effects, which is similar to the number of people reporting adverse effects while taking a placebo.
Psychiatric Conditions
Despite it use and effectiveness in treating mild to moderate depression, St. John's wort has caused some users to experience suicidal and/or homicidal thoughts or tendencies. The University of Maryland Medical Center advises that it should not be used to treat people with severe depression or bipolar disorder. When used in people taking prescription antidepressants, it can cause a worsening of symptoms or a potentially severe condition called serotonin syndrome. Never self-treat depression or any other mental illness with St. John's wort without being properly diagnosed by a medical professional.
Sexual Side Effects
When used in men, St. John's wort may cause sexual dysfunction such as impotence, according to the National Institutes of Health. Studies conducted on animals indicate that it may cause delayed ejaculation.
Light Sensitivity
Use of St. John's wort can also make the skin more sensitive to the effects of light. Fair-skinned individuals who regularly take St. John's wort should should take precautions when exposed to the sun and avoid tanning beds and sun lamps, the University of Maryland Medical Center advises. Consult a medical professional before taking St. John's wort.
Gastrointestinal Distress
Another possible side effect of St. John's wort supplements is an upset stomach or nausea, according to the University of Virginia Health System.
Headaches
Headaches and dizziness have also been reported in people using St. John's wort.
Difficulty Sleeping
Some users of St. John's wort may develop sleep problems as a side effect. Insomnia, sleep disturbances, and vivid dreams and nightmares have all been reported, according to the University of Virginia Health System.
Skin Reactions
Skin reactions are another potential effect of St. John's wort. In addition to rashes, some people have experienced a burning, itching, prickling or tingling sensation in the skin after using the supplement, according to the University of Virginia Health System.
Tiredness
Some people taking St. John's wort may experience fatigue or may feel as though they have taken sedatives, according to the National Institutes of Health. Remember to always consult a health-care professional before using St. John's wort.
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