Nonsteroidal anti-inflammatory drugs, or NSAIDs, are medications used to treat mild to moderate pain, fever and inflammation caused by various medical conditions. Some patients take NSAIDs for a long time due to such chronic conditions as osteoarthritis, rheumatoid arthritis and chronic back pain. According to the U.S Food and Drug Administration, taking NSAIDs for an extended period of time may lead to life-threatening side effects.
Heart Attack and Stroke
According to the U.S Food and Drug Administration, long-term use of NSAIDs may increase the risk of blood clots, heart attack and stroke. NSAIDs interfere with the formation of platelets, and this can lead to abnormal platelets that clog blood vessels and create blood clots. Blood clots can cause a heart attack or stroke.
Gastrointestinal Ulcers and Bleeding
People who take NSAIDs for a long time are at risk for developing stomach ulcers and bleeding, says the U.S Food and Drug Administration. The risk of stomach ulcers and bleeding rises with increased dose and duration of NSAIDs use. Bleeding and ulceration can occur at any time, and with no symptoms, in patients receiving NSAIDs therapy chronically. Patients with active ulcers and bleeding should consult their doctor before using NSAIDs. Patients should avoid alcohol as the combination of NSAIDs and alcohol can cause stomach bleeding.
Kidney and Liver Failure
According to FamilyDoctor.org, long-term use of NSAIDs may cause damage to the kidneys. NSAIDs create a decrease in blood flow to the kidneys, which can result in kidney damage. Signs of kidney damage include decreased urine output, swelling of the legs and ankles, sudden weight gain, wheezing and shortness of breath. NSAIDs can also cause liver damage. Signs of liver damage include pain at the right upper abdominal region, dark urine, skin itching, and yellowing of the eyes and skin.
