The slang phrase "tren steroids" refers to use of trenbolone, a performance-enhancing drug invented in 1963 says "Advances in Environmental Biology.” This veterinary medication increases muscle size and caloric appetite in animals. Readily available, athletes such as body builders and weight lifters use tren steroids to enhance their physique and improve their strength. These drugs alter the body's natural testosterone system which is responsible for development and growth. Trenbolone is considerably more potent than testosterone, but it can cause both short-term reactions and long-term effects.
A 2007 report described in the journal "Advances in Environmental Biology" tested the effects of tren steroids on human lymphocytes, or white blood cells. These cells, maintained in a petri dish culture, are rarely abnormal. Yet, the addition of trenbolone produced a dramatic increase in the number of abnormal cells. This increase represents a change in chromosomal structure. Most cells experiencing such a change die off. Yet surviving cells can cause genetic changes in the host and the offspring.
A 2007 study by H. K. Hotchkiss presented in the periodical "Toxicology Letters" looked at the impact of trenbolone in female rats. Fetuses exposed to tren steroids prior to birth displayed delayed puberty and deformed genitals. Trenbolone causes similar physical changes in male rats. A 2002 report in "Toxicological Sciences" showed that tren steroids shrank the adrenal gland. This study also indicated that trenbolone was far more effective when administered through the skin than by the mouth. This finding may explain why body builders typically use tren steroids in home-made transdermal preparations, says “Toxicology Letters.”
A 1999 experiment offered in the "Journal of Animal Science" assessed the lipid content of steer meat. Lipids include natural chemicals like fats, vitamins and sterols. Cholesterol is a lipid of particular interest due to its potential role in heart disease. Trenbolone pellets are often implanted into steers to increase their growth. Such implants, unfortunately, increase the cholesterol content present in steak. People may also absorb steroid additives directly from steak as well, says the "Journal of Animal Science.”
Two reports described by the "International Programme on Chemical Safety" observed changes in behavior induced by tren steroids. Male and female rats were given active metabolites of trenbolone: 17-alpha-trenbolone or 17-beta-trenbolone. Males, but not females, exhibited drug-induced behavioral changes. These rats frequently salivated and consumed more food than controls.
A 2007 investigation in the "Journal of Toxicology and Environmental Health" evaluated the effects of tren steroids on the immune system. Male rats received either trenbolone, testosterone, or saline. A delayed-type hypersensitivity test measured immune function. For this test, a potential allergen is placed under the skin, and the appearance of a rash within 72 hours indicates a positive reaction. A positive reaction indicates normal immunity. Rats given tren steroids showed less rash relative to those given either testosterone or saline.
- "Advances in Environmental Biology": Chromosomal Damage Induced by Androgenic Anabolic Steroids
- "Toxicology Letters"; In Utero Exposure to the Environmental Androgen Trenbolone Masculinizes Female Sprague-Dawley Rats; H. K. Hotchkiss et al.; Nov. 1, 2007
- "Journal of Animal Science"; Effect of Anabolic Implants on Beef Intramuscular Lipid Content; S. K. Duckett et al.; May 1999
- "International Programme on Chemical Safety": Detailed Studies on Trenbolone Acetate
- "Journal of Toxicology and Environmental Health, Part A"; An Environmental Androgen, 17beta-trenbolone, Affects Delayed-Type Hypersensitivity and Reproductive Tissues in Male Mice; H. K. Hotchkiss et al.; Jan. 15, 2007