Ganoderma, or Ganoderma lucidum, is a type of mushroom that is used medicinally as an herbal supplement. Among its purported medicinal uses are boosting the immune system in HIV and AIDS patients, preventing inflammation and fatigue and treating hypertension, high cholesterol and viral infections, according to Memorial Sloan-Kettering Cancer Center. When used medicinally, both the fruiting body and the mycelium are used to make herbal supplements. Studies regarding the medicinal effectiveness have been inconclusive in some cases. Exactly how ganoderma works in the body is not known. Consult with a knowledgeable medical practitioner before using ganoderma--also called reishi mushrooms--before using it to improve your health.
Gastrointestinal Distress
Some users of ganoderma can develop gastrointestinal distress, including upset stomach, nausea and vomiting, according to Drugs.com. Some people have also experienced diarrhea and constipation as side effects. Bloody stools have also been reported. Always discuss these risks with your doctor before using ganoderma.
Nose and Throat
Ganoderma supplements can also cause the throat, nose and mouth to feel dry or irritated, and nosebleeds may develop in some users, according to Sloan-Kettering. Fully discuss the potential risks of ganoderma with your doctor before using it to improve your health.
Skin Reactions
Reishi mushrooms can trigger skin reactions such as a contact dermatitis rash in some users, according to Drugs.com. The rash may be itchy, and in some cases the skin may be itch even in the absence of a rash.
Bleeding
Ganoderma can increase a person's risk of experiencing severe bleeding, according to Sloan-Kettering. Because of this risk, people with bleeding disorders or those about the undergo surgery or major dental work should consult with their doctor.
Hypotension
Ganoderma may also have hypotensive properties that cause a decrease in blood pressure, according to Sloan-Kettering. Because of this, it is sometimes used as a herbal remedy for high blood pressure. However, it should not be used by people with low blood pressure or those taking medications to lower blood pressure without first consulting with a medical professional.



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