Hives are weal-like, patchy formations that commonly erupt on the upper chest though they can affect the entire body. Also called urticaria, hives develop when blood vessels in the body leak fluid into the skin. This is a histamine-type reaction that may occur in response to infections, foods, medications or direct contact with an allergen MedlinePlus reports. Drugs that cause hives usually do so as an indication of a sensitivity or allergy to the medication. Some drug allergies are more common than others.
Penicillin
Penicillin, an antibiotic used to treat bacterial infections, may cause hives. This could be a sign of allergic reaction to the medication and warrants emergency medical care, Drugs.com indicates. Hives are considered a serious side effect because of the possible danger of anaphylaxis, a condition that is life-threatening.
Aspirin
Aspirin or acetylsalicylic acid, an over-the-counter non-steroidal anti-inflammatory drug, or NSAID, may cause hives if the user has an allergic reaction to the medicine. Hives warrant a trip to the emergency room because the reaction following may occur severely. Hives can indicate an allergic response to the drug that also may include other symptoms such as swelling of the face and throat, and difficulty breathing.
Ibuprofen
People often take ibuprofen, another NSAID, to treat all forms of pain, particularly that associated with inflammation such as arthritis. Both over-the-counter and prescription-level versions of ibuprofen exist, and both can induce hives as side effects.
Doxepin
The tricyclic antidepressant doxepin, used to treat depression and anxiety, may cause hives as an allergic reaction, Drugs.com reports. Doctors also may prescribe this medicine to treat insomnia.
Famotidine
Famotidine treats heartburn, indigestion and ulcers by decreasing the level of acid produced in the stomach. Famotidine, whether sold over-the-counter or via prescription, can cause hives as an allergic reaction, Drugs.com reports.
