Lupron commonly treats prostate cancer and enlarged prostate in men. Prostate cancer needs the hormone testosterone to grow. Lupron is a hormone that slows the production of testosterone in men. Lupron stops the production of luteinizing hormone, which is responsible for stimulating the production of testosterone in the testicles. Slowing the production of testosterone also slows or shrinks prostate cancer growth. Lupron injections typically occur once a month or as little as every four months depending on the dose given.
Sexual Dysfunction
Several possible sexual side effects commonly occur with the use of Lupron. Sexual side effects occur because of the decreased production of testosterone, a common male hormone. Chemocare.com lists hot flashes, decreased libido and erectile dysfunction as common side effects of Lupron injections. Less common side effects occurring in 10 percent to 29 percent of patients include depression, enlargement of breast tissue and breast pain. Abbott, the maker of Lupron, also reports testicular shrinkage as a possible side effect.
Tumor Flare Effects
Tumor flare refers to the reaction the cancer has to Lupron treatment. This typically occurs in the first two weeks of treatment. "The Chemotherapy Source Book" lists urinary problems and bone pain as side effects associated with tumor flare. Urinary problems include retention of urine, being unable to fully empty the bladder, and urinating frequently.
Various Side Effects
Other side effects associated with Lupron reported by Chemocare.com include pain and soreness at the injection site, swelling in hands and feet, muscle loss, generalized weakness and sweating. Lupron may also increase cholesterol levels, causing high cholesterol in some patients. Nausea and vomiting have also been reported with the use of Lupron. Abbott Laboratories reports dizziness, headache, breathing difficulties, skin reactions and insomnia as side effects reported in clinical trials of Lupron. Rare but life-threatening side effects include heart failure and blood clots.
References
- Chemocare.com: Lupron Depot
- "The Chemotherapy Source Book"; Michael C. Perry, PhD.; 2007
- Lupron Prescription Information
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