Antihistamines are drugs that block the effects of histamine, which is a substance released by immune cells throughout the body as part of the allergic response. People use these drugs to relieve or prevent the symptoms associated with allergies and often as sleep aids. According to PDR Health, antihistamines interact with some commonly used drugs and produce side effects.
Barbiturates
Barbiturates are central nervous system depressants that act on the brain and depress the central nervous system. Physicians prescribe barbiturates to control seizure activity associated with epilepsy. Administered before surgery, barbiturates relieve anxiety. These drugs have been used to treat insomnia and anxiety. Barbiturates are available by prescription only. Overuse can lead to dependency and addiction. Central nervous system depression is increased if barbiturates are taken with antihistamines. A decrease in breathing rate and heart rate are symptoms of central nervous system depression.
Haloperidol
Haloperidol belongs to a group of antipsychotic drugs prescribed to reduce the symptoms of mental disorders such as schizophrenia. This drug blocks the dopamine receptors in the brain. Haloperidol controls the involuntary motor and speech tics associated with Tourette's syndrome. Antihistamines interact with haloperidol to cause cardiac arrhythmias, central nervous system depression and psychomotor impairment, such as the inability to concentrate or focus. Interaction of the two drugs causes adverse anticholinergic effects such as drowsiness, blurred vision, increased heart rate and dry mouth.
Sodium Oxybate
Sodium oxybate belongs to the group of central nervous system depressants. Physicians prescribe this drug to treat the sudden loss of muscle strength and daytime drowsiness associated with narcolepsy. Available only by prescription, sodium oxybate is a narcotic also used for sedation. The Mayo Clinic says that antihistamines interact with central nervous system depressants. Antihistamines interact with sodium oxybate and increase the risk of central nervous system depression and psychomotor impairment.
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