Allegra-D is a drug that contains pseudoephedrine and fexofenadine. Pseudoephedrine is a decongestant that helps to shrink dilated blood vessels that can cause a stuffy nose. Fexofenadine is an antihistamine that reduces the amount of histamine in the body. Like many other medications, Allegra-D has a number of side effects that users should be aware of while completing a course of treatment.
Sleep Problems
Allegra-D can cause sleep problems, according to the consumer drug information sheet at Drugs.com. Excitability and restlessness can be caused by the pseudoephedrine in Allegra-D and insomnia (difficulty sleeping) can also occur. The National Institutes of Health attributes these side effects to the similarity pseudoephedrine has to ephedrine and amphetamines.
Mood and Behavior Changes
Allegra-D is known to affect mood and behavior in children and adults. It can cause confusion, unusual thoughts and hallucinations, problems with memory and concentration and unusual behaviors. These side effects should be reported to a doctor immediately. The treating physician may discontinue Allegra-D and prescribe a different drug.
Skin Effects
Allegra-D has a number of side effects that affect the skin, including redness, tingling, itching, skin rash and warmness under the skin. Some of these side effects indicate an allergic reaction to the drug, so they should be reported to a physician if they persist. If an allergic reaction occurs, Allegra-D can be replaced by another drug that contains an antihistamine and decongestant.
Nervous System
While rare, some side effects of Allegra-D can impact the nervous system. Side effects as uncontrollable shaking, seizures and fainting have been reported. These side effects can cause serious health consequences. Report them to your doctor immediately.
Digestive System
Some Allegra-D side effects also impact the digestive system. You might have nausea, stomach pain, dry mouth, heartburn, upset stomach and loss of appetite. If these systems do not go away after taking several doses of the drug, report them to your doctor so alternate treatment can be considered.
Cardiovascular System
Serious side effects of Allegra-D can affect the cardiovascular system. These side effects include an irregular heartbeat or a pounding heartbeat. Drugs.com warns users that Allegra-D may cause high blood pressure that can be signaled by chest pain and severe headache. Seek medical attention immediately if these side effects occur.
Urinary System
While uncommon, Allegra-D can also cause side effects that create changes in the urinary tract, resulting in difficulty or painful urination. These are considered serious side effects, so they should be reported to a physician immediately if they occur.



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