Alli is an over-the-counter, low-dose version of orlistat (Xenical), a drug used to treat obesity. Sold to overweight adults over the age of 18, it's intended to be used alongside a healthy, low-calorie, low-fat diet with exercise. Although it's believed to be a major breakthrough, it's important to know all the facts before taking the plunge.
History
Alli---pronounced "Ally"---is the first FDA-approved over-the-counter weight loss pill. It was first available in the United States beginning in June, 2007 and is sold as 60-, 90- and 120-count packs of 60mg pills. It is a half dosage of its prescription-only weight-loss counterpart Xenical. The manufacturers of Alli also published "The Alli Diet Plan," which endeavors to help users make lifestyle choices that yield results.
How it Works
Unlike previously available appetite suppressants, Alli works by decreasing the fat intestines absorb, in turn reducing the number of calories the body absorbs. Alli disables lipase, the enzyme in your digestive tract that breaks down dietary fat so it can be stored for energy; consequently, the fat that's not broken down goes through the intestines and out the bowel. Alli is supposed to be taken with meals that contain fat, but no more than 15g of fat per meal.
Weight Loss
According to the Mayo Clinic, the average weight loss associated with the prescription-strength version Alli is about 6 lbs. more than with diet and exercise alone, meaning Alli users might average a loss of no more than 3 lbs. a year that can be attributed directly to taking the pill.
Side Effects
Taking Alli most notably causes changes in the bowel. Common symptoms are loose stools, diarrhea, urgent and more frequent bowel movements and gas with oily discharge. It poses a risk among those who take blood-thinning medications. It's also important to know taking Xenical (also marketed as orlistat) decreases the absorption of fat-soluble vitamins, such as D, E and A; it becomes necessary to take a dietary supplement at another time of day than when Alli is being taken to ensure proper nutrient intake.
Duration
Most weight loss associated with Alli tends to occur within the first six months of taking the medication. Many people who have taken Alli regain the weight they lost after going off of the medication, so it's integral to adjust eating habits permanently and maintain a regular exercise regimen during the diet and afterward to keep pounds at bay.
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