Numerous diseases can cause tingling sensations. According to MedlinePlus from the National Institutes of Health, tingling sensations in the extremities--or other parts of the body--are often accompanied by numbness or decreased sensation, and both tingling and numbness are abnormal sensations that indicate an underlying health problem or disease. MedlinePlus states that treatment for numbness and tingling can eliminate the sensations or prevent them from getting worse.
According to the National Heart Lung and Blood Institute, or NHLBI, pernicious anemia is a condition in which a person's body is unable to manufacture sufficient amounts of healthy red blood cells because there is not enough vitamin B12 present. The NHLBI states that a person with pernicious anemia is unable to absorb sufficient vitamin B12 from food because of a lack of intrinsic factor--a glycoprotein synthesized by the stomach's parietal cells. The lack of intrinsic factor results in vitamin B12 deficiency, along with numbness and tingling in the hands and feet. According to MedlinePlus, other common symptoms associated with pernicious anemia include diarrhea, fatigue, anorexia or loss of appetite, difficulty concentrating, shortness of breath and balance problems.
The National Institute of Diabetes and Digestive and Kidney Diseases, or NIDDK, states that a person with diabetes, especially a person who has had the disease for 25 years or more, may develop nerve damage throughout the body, and that although some individuals with nerve damage do not experience symptoms, others may feel pain, tingling and numbness in the upper and lower extremities. The NIDDK reports that approximately 60 to 70 percent of people with diabetes suffer from some type of diabetic neuropathy or nerve damage, and that other common symptoms associated with diabetic neuropathy include muscle wasting in the hands and feet, nausea and vomiting, diarrhea or constipation, dizziness upon standing, sexual dysfunction and a feeling of general weakness.
Carpal Tunnel Syndrome
According to the National Institute of Neurological Disorders and Stroke, or NINDS, carpal tunnel syndrome occurs when the median nerve--a large nerve coursing through the forearm and into the hand--becomes impinged at the wrist as it travels through the carpal tunnel. The carpal tunnel is a narrow passageway through which numerous tendons and the median nerve pass. Swelling in the carpal tunnel can compress the structures running through the tunnel, including the median nerve, which often causes pain, weakness, and numbness and tingling in the hand, wrist and forearm. The NINDS states that carpal tunnel symptoms often manifest gradually, and tingling sensations, along with burning or itching, are sometimes among the first symptoms reported by a person with carpal tunnel syndrome.