Crohn's disease is an inflammatory disorder of the digestive system. It usually affects the last part of the small intestine known as the ileum, as well as the colon, which is part of the large intestine. Inflammation caused by Crohn's disease may damage the digestive system, resulting in further health complications such as narrowing of the colon. According to the National Health Service, most cases of Crohn's disease first occur in people aged 16 to 30 although it can sometimes affect children and people of other ages. The majority of Crohn's disease sufferers will need surgery to relieve symptoms and repair damage caused by inflammation, but some medicines may also be used to help manage symptoms. (See Reference 1) Corticosteroids are often used in Crohn's disease treatment because they help to suppress inflammation. However, they are very strong drugs and may cause side effects. (See Reference 2)
Budesonide
Budesonide, which is also known by the brand name of Entocort EC, is a corticosteroid often used in the treatment of Crohn's disease. It is indicated for the treatment of mild-to-moderate Crohn's disease involving the ileum and colon and may be also used for the maintenance of clinical remission of Crohn's disease for up to three months. A doctor should advise as to the correct dose and treatment schedule of budeonside. According to RxList.com, the most common adverse events assocaited with budenoside are headache, nausea and respiratory infections. Budenoside may also lead to hypercortisolism, a condition characterized by high levels of the hormone cortisol. (See Reference 2)
Prednisone
Prednisone is another commonly-prescribed corticosteroid for Crohn's disease. According to the National Institute of Diabetes and Digestive and Kidney Diseases, prednisone is usually prescribed at a large dose in the early stages of Crohn's disease, when the symptoms are at their most aggessive. The dosage is then reduced once symptoms are under control. Prednisone, like other corticosteroids may cause serious side effects and should only be used under the direction of a medical professional. (See Reference 3)
Hydrocortisone
In severe cases of Crohn's disease, a doctor may recommend a corticosteroid called hydrocortisone, which is similar to the hormone cortisol that is produced by the adrenal glands. Hydrocortisone will usually be injected into a large muscle or into a vein. It may also be added to an intravenous fluid administered via a catheter placed in a vein. The dose and duration of treatment will depend on severity of the condition and how a patient responds and should only be used as advised by a doctor. (See Reference 5)
