Excedrin migraine was the first FDA-approved over-the-counter migraine medicine used to treat the debilitating pain associated with severe migraines according to Novartis, the pharmaceutical company that makes Excedrin. There are three primary ingredients in Excedrin Migraine: aspirin, acetaminophen, and caffeine. Aspirin improves blood circulation by reducing swelling and the likelihood of blood clots. Acetaminophen is minimizes fever and pain. Caffeine works with aspirin and acetaminophen to alleviate headache pain by stimulating the nervous system.
Common Abdominal Effects
Abdominal distress is a typical side effect of acetaminophen and aspirin use according to the Mayo Clinic and the National Institute of Health. Swelling of the abdomen, cramps, diarrhea, vomiting and nausea are representative examples.
Skin Abnormalities
Skin abnormalities are also attributed to both acetaminophen and aspirin use. Itching, ulcers, hives, and rashes are typical examples; however, rare side effects include red or white spots. The Mayo Clinic suggests that any skin imperfections may be reversible when medication use is stopped.
Irregular Bleeding
The National Institute of Health indicates that bloody stool and urine are possible rare side effects of aspirin use. Since aspirin acts by reducing blood coagulation and improve blood flow, internal irregular bleeding and bruising may cause unstoppable blood loss.
Reye's Syndrome
Excedrin Migraine, which contains aspirin, must only be given to people younger than 18 under a doctor's supervision. Reye's syndrome is described by the Mayo Clinic as a rapid swelling of organs, including the brain and liver, resulting in eventual death by organ failure.
Rebound Migraines
The National Headache Foundation indicates that rebound migraines are possible with excessive caffeine use. Since Excedrin Migraine contains caffeine, you should monitor your dietary consumption of caffeine while using this medication. Be aware that excessive use as well as withdrawal can cause painful headaches to occur. The National Institute of Health also indicates that caffeine may cause high anxiety and heart rate. If you experience either of these conditions, please consult a doctor.
