Drugs.com notes that Darvocet-N is an Eli Lilly branded prescription drug approved by the FDA in 1972 for the purpose of mild to moderate pain management. The active ingredients in Darvocet-N are propoxyphene napsylate and acetaminophen, both analgesics. As cited in the "Compendium of Pharmaceuticals and Specialties," Darvocet-N is offered in two formulations: 50 mg of propoxyphene with 325 mg of acetaminophen per tablet, and 100 mg of propoxyphene with 650 mg of acetaminophen. Both acetaminophen and propoxyphene, which is a narcotic, can cause negative side effects and present dangers which justify Darvocet warnings.
Warnings of Overdose and Suicide
According to Rxlist.com, there have been many cases of accidental and intentional overdose with propoxyphene either alone or in combination with alcohol. Deaths can occur within the first hour of overdose. Because many propoxyphene-related deaths have occurred in patients with histories of depression or suicidal attempts, Daily Med warns that Darvocet-N or any propoxyphene product should not be prescribed for depressed, suicidal or addiction-prone patients. Limiting alcohol intake while on Darvocet-N is also extremely important due to possible liver failure risk brought on by the mixture.
Warnings of Respiratory Depression
Rxlist.com warns that respiratory depression is the chief hazard from all opioids, such as propoxyphene. Respiratory depression is a reduced autonomic breathing response, which can lead to apnea and death. Drugs.com adds that respiratory depression occurs most often in geriatric patients following large initial doses. Darvocet-N should be used with extreme caution in patients with chronic obstructive pulmonary disease or other breathing problems.
Warnings of Severe Blood Pressure
Darvocet-N, like all pain killers containing narcotics, may cause sudden and severely reduced blood pressure, especially in patients who have depleted blood volume, warns the "PDR Guide to Drug Interactions, Side Effects, and Indications." Darvocet-N may also produce orthostatic hypotension in patients suddenly standing up from a seated position. Risks of falls and fainting are substantial.
Drug Interaction Warnings
The use of propoxyphene with any CNS depressants, including alcohol, can result in serious adverse events including death, warns Daily Med. Therefore, propoxyphene should not be given to patients already taking sedatives, tranquilizers, muscle relaxants, antidepressants or other CNS-depressant drugs.
Drug Dependence Warning
Like all narcotics, propoxyphene also carries a risk of physical and psychological addiction and dependency. Because Darvocet-N contains acetaminophen, the simultaneous use of other pain killers, such as Tylenol or Advil, is also warned against. Acetaminophen-related liver damage is a real risk.
Warning Against Operating Equipment / Machinery
Rxlist.com warns that propoxyphene may impair the mental and/or physical abilities required to operate machinery and equipment or drive a car.
References
- Drugs.com: Darvocet-N Side Effects
- "Compendium of Pharmaceuticals and Specialties"; Canadian Pharmacists Association; 2010
- Rxlist.com: Darvocet-N Warnings
- Daily Med: Darvocet-N Warnings
- "PDR Guide to Drug Interactions, Side Effects, and Indications"; PDR Staff; 2009
