Aggrenox reduces the risk of secondary stroke in patients who have had a transient ischemic attack or ischemic stroke. Aggrenox is a capsule taken twice daily with or without food. The duration of therapy is lifelong unless the potential risk of bleeding outweighs the risk of stroke. Aggrenox contains two active ingredients because the individual components of Aggrenox are not as effective as the combination.
Aspirin
Each Aggrenox capsule contains 25mg of immediate-release aspirin or acetylsalicylic acid. Aspirin is a common antiplatelet medication available over-the-counter and in prescription medications. Indications for use range from providing pain relief to prevention of heart attack and stroke. Aspirin makes platelets less sticky, helping prevent blood clot development. Avoid taking over-the-counter aspirin while on Aggrenox unless advised otherwise by a physician. Aspirin-containing products should be avoided in patients with aspirin allergy or those under 19 years of age because of an increased risk of Reyes Syndrome.
Dipyridamole
Dipyridamole is an antiplatelet medication available by prescription only. Aggrenox contains 200mg of extended-release dipyridamole per capsule. Dipyridamole is available without aspirin in a product branded Persantine which is indicated only for prevention of blood clot development after a prosthetic heart valve replacement. Persantine and Aggrenox are not interchangeable. Dipyridamole works differently than aspirin but the end result is the same as it makes platelets less likely to clump together to create blood clots. Those with a history of chest pain or angina should discuss this with a physician before taking dipyridamole as it can cause chest pain in some patients.
Common Side Effects
Common side effects of Aggrenox include headache, stomach pain, nausea, diarrhea and increased bleeding risk. Headaches with Aggrenox typically diminish with continued use. In cases of severe headaches the dose can be reduced for a short period and then increased back to the recommended twice daily dosing. Food does not interfere with Aggrenox but taking with food may prevent an upset stomach. Aggrenox can increase the risk of gastrointestinal bleeding or brain hemorrhage. Avoid other aspirin-containing products, nonsteroidal anti-inflammatory drugs and alcohol to minimize the risk of bleeding. Stop Aggrenox and seek medical attention immediately for symptoms of weakness, black and tarry stools, or coughing up blood.
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