Nexium is the brand name for the drug esomeprazole magnesium, a prescription treatment for heartburn and other symptoms that result when the stomach acid flows back up the esophagus, says Drugs.com. The drug can also be used to treat gastroesophageal reflux disease and improve damage caused by persistent acid damage. As with any drug, Nexium is contraindicated for some individuals due to health conditions or the risk of drug interactions.
Ingredient Sensitivities
Individuals with a known allergy or sensitivity to any of the ingredients in Nexium should seek other treatment methods. Ingredients that may cause such reactions include the active ingredient esomeprazole as well as supporting ingredients called benzimidazoles that are necessary components of the medication according to the manufacturer, AstraZeneca.
Antibiotic Interaction
Certain bacterial infections in the digestive tract, such as H. pylori, can exacerbate or be caused by gastroesophageal reflux disease. An antibiotic is often prescribed to treat these infections. Drugs.com warns consumers to check with a doctor before using Nexium if amoxicillin, clarithromycin or similar antibiotics are being used. The risks associated with an interaction between Nexium and some antibiotics can be severe.
Other Drug Interactions
Individuals with various other prescription medications may have an increased risk of adverse side effects by taking Nexium. Drugs.com warns that the effects of some prescription drugs may be increased, decreased or altered when taken with Nexium. Known problem drugs include diazepam, digoxin, iron salts, ketoconazole and warfarin. It is not advisable to discontinue these prescription drugs to take Nexium. Instead, patients can explore other heartburn treatment options with a doctor.
Pregnant or Breastfeeding
Nexium use while pregnant or breastfeeding has yet to be studied adequately to determine the risk of harm to the baby, says Drugs.com. This suggests that the drug has yet to show a definite adverse effect on infants but without extensive research it is best to seek alternative treatments.
Liver Disease or Failure
Individuals with liver disease or liver failure may not be suitable candidates for Nexium use, says eMedTV.com. As Nexium is processed in the liver, patients with liver damage may not be able to process the medication appropriately. Under these circumstances the dose amount for Nexium should not exceed 20 mg per day to minimize potential strain placed on the liver.
