Omeprazole, also known by the brand names Prilosec and Losec, is used in the treatment of acid reflux disease, or GERD, inflammation of the esophagus and H. pylori infection. Omeprazole helps infants with these conditions by decreasing stomach acid. As with all medications, infants taking omeprazole may experience side effects, most of which are mild and may decrease or resolve after regular use. However, some infants may have an allergic reaction to omeprazole, which could lead to serious side effects that require immediate attention.
Gastric Side Effects
According to KidsHealth.org, some infants may experience gastric side effects during omeprazole treatment such as diarrhea, nausea and vomiting. Abdominal pain has also been noted. Smaller, more frequent feedings, as well as frequent mouth care may help alleviate some of these symptoms. Additionally, omeprazole is supposed to be given before a meal, which may also help decrease the incidence of gastric side effects.
Upper Respiratory Infection
Another common side effect of omeprazole use in infants is upper respiratory infection. Interestingly, this side effect is associated primarily with pediatric users of the drug, as adults are less likely to experience respiratory symptoms. Possible respiratory side effects include upper respiratory infection, wheezing and cough. Rarely, nosebleed and sore throat are reported.
Headache
Certain patients may experience headaches while taking omeprazole. Unfortunately, it is hard to assess if an infant is experiencing headaches with this treatment, since they are unable to verbalize pain. Some signs that might suggest an infant is in pain include restlessness, irritability, sleeplessness and the inability to be consoled. If headache or other pain is suspected while taking omeprazole, a doctor should examine the infant to determine if omeprazole therapy should be continued.
Allergic Reactions
All medications have the potential to cause allergic reactions. Infants taking omeprazole for the first time should be monitored closely for symptoms of an allergic reaction such as wheezing, itching, severe cough, blue skin color or swelling of the face, lips, tongue or throat. If an infant experiences any of these symptoms, immediate emergency medical attention is required.



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