Estradiol is a medication derived from the female sex hormone estrogen. It is used for treating moderate to severe menopause symptoms such as hot flashes and vaginal dryness. It may be prescribed when estrogen levels are low or a patient experiences inflammation or thinning of the vaginal walls. Estradiol may also be prescribed for the prevention of osteoporosis or as part of a cancer treatment regimen for breast and prostate cancer, among others. Estradiol is available as tablets, cream, emulsion, gel, injection, patch and vaginal ring.
Breast Tenderness and Enlargement
Estradiol may lead to changes in the breasts and both men and women. Patients may experience breast tenderness and swelling. Breast enlargement and nipple pain may also occur. These adverse reactions are not harmful, but may make patients, particularly men, uncomfortable, in which case patients can speak with a physician who can switch the medication to one that does not produce these side effects.
Vaginal Side Effects
Drugs.com states that this medication may cause vaginal discharge or itching. Women may also notice changes in the frequency and flow of their menstrual periods, especially if they are postmenopausal. These effects should be brought to the attention of a physician.
Effects on the Heart
Estradiol increases the risk of developing high blood pressure, stroke, heart attack and blood clots. The "Drug Information Handbook" warns that patients who have cardiovascular disease or heart dysfunction should use the medication with caution. The risk of developing these effects is significantly increased in postmenopausal women who are on conjugated equine estrogens in combination with medroxyprogesterone acetate. Patients should always inform the physician of their entire medical history and all prescription and nonprescription medications they are taking.
Nausea and Vomiting
Nausea and vomiting are common side effects of Estradiol use, according to Drugs.com. Abdominal cramping and bloating may occur, as well. Patients can take the tablet form with meals to help with these adverse effects. These side effects typically decrease with continued use of the drug.
Hair Loss
A unique side effect of Estradiol is loss of scalp hair. The amount of hair loss depends on the dosage and length of therapy. Patients concerned about this side effect should discuss it with a health care professional.
Skin Irritation
The Estradiol patch may affect the skin at the site if application. The "Drug Information Handbook" explains that patients may experience redness and irritation. Burning and stinging may also develop. If patients develop itchiness, hives or redness that spreads to other areas, they may be experiencing an allergic reaction and should seek medical attention right away.
References
- Drugs.com: Estradiol
- "Drug Information Handbook"; Charles F. Lacy, Lora L. Armstrong, et al.; 2009
Member Comments