Aplodan is a nutritional supplement manufactured by the company, MuscleTech, and ismarketed as, "The World's Only Clinically Engineered Muscle Fiber Hyperactivator," according to a vendor's website that lists the manufacturer's claim. Not surprisingly, Aplodan users are predominantly weight trainers such as bodybuilders and other athletes. Aplodan is packaged as 111 silver capsules, each containing 1,010 mg of active ingredients, as well as additional inactive ingredients.
2-(Carbamimidoyl-Methyl-Amino)ethoxyphosphonic Acid
One of the active ingredients in Aplodan is listed as 2-(Carbamimidoyl-Methyl-Amino)ethoxyphosphonic acid, which is the chemical formula for alpha-lipoic acid. Alpha-lipoic acid is known as an antioxidant, but not for building muscle, or activating muscle fibers or increasing strength. According to the University of Maryland Medical Center, alpha-lipoic acid is an antioxidant made by the body and found in every cell, where it helps turn glucose into energy. As such, alpha-lipoic acid can lower blood sugar levels, which is why it is recommended for diabetics as a supplement. A major dietary source of alpha-lipoic acid is red meat, especially organ meats.
1,2-Dithiolane-3-Pentanoic Acid
The other active ingredient in Aplodan is listed as 1,2-Dithiolane-3-Pentanoic acid, which is the chemical formula for creatinol-o-phosphate. Creatinol-o-phosphate is a structural analog of creatine, and may serve as a source of creatine. According to MayoClinic.com, creatine is made in the human body from amino acids, mainly in the kidney and liver, and transported in the blood for use by skeletal muscles, where 95 percent of the body's creatine resides. Further, several quality studies have reported an increase in lean muscle mass and strength with the use of creatine.
Once inside of cells, creatinol-o-phosphate loses its phosphate attachment where it dissociates to form the high-energy molecule, ATP, which can be used in muscular contractions, according to "Molecular Cell Biology." Thus, creatinol-o-phosphate contributes to the production of cellular ATP molecules and may serve as a source of creatine, which could then be complemented by the presence of alpha-lipoic acid as it is known to increase creatine uptake in muscle cells.
Inactive Ingredient
Aplodan has a number of inactive ingredients and they include microcrystalline cellulose, dicalcium phosphate, stearic acid, hydroxylpropyl methylcellulose coating, polydextrose, titanium dioxide, talc powder, maltodextrin, medium chain triglycerides, sodium carboxymethylcellulose, dextrose monohydrate which may contain corn and wheat, mica, soy lecithin, croscarmellose sodium, magnesium stearate, FD&C Blue #2 dye, FD&C Yellow #6 dye, FD&C Red #4 dye, and the sweetener sucralose.
References
- Vendor's Site: Aplodan Information and Ingredients
- University of Maryland Medical Center: Alpha-lipoic Acid
- MayoClinic.com: Creatine
- "Molecular Cell Biology"; H. Lodish et al; 2007



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