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The Effects of Hydrocodone & Effexor

author image Marie Cheour
Marie Cheour had her first article published in 1995, and she has since published more than 40 articles in peer-reviewed publications such as "Nature" and "Nature Neuroscience." She has worked as a college professor in Europe and in the United States. Cheour has a Ph.D. in cognitive psychology from the University of Helsinki.
The Effects of Hydrocodone & Effexor
Pharmacist holding prescription medication bottles. Photo Credit Jupiterimages/Stockbyte/Getty Images


Hydrocodone and effexor, or venlafaxine, are two very different pharmaceutical drugs that are prescribed for varying reasons. Hydrocodone is an artificial opiate that is used to treat pain and relieve coughing for its dulling and analgesic effects, whereas venlafaxine is generally used to treat depression and anxiety due to the role it plays when introduced into the brain. Although these two drugs are drastically different, they share some similarities in the effects they cause.

Intended Effects

Hydrocodone is an opiate, meaning it is derived from the poppy plant. This gives it qualities which are useful in managing pain and calming patients. On the other hand, venlafaxine causes changes in the levels of certain neurotransmitters in the brain. This then causes changes in mood, making the drug useful in managing depression and anxiety.

Side Effects

No drug can ever cause only one desired effect. Hydrocodone and effexor are no exceptions to this and are known to cause several side effects. Side effects shared by these drugs include drowsiness, dizziness, narrowing of the pupils, dry mouth or throat and constipation, says the U.S. National Library of Medicine. Side effects of hydrocodone that are not caused by effexor include changes in mood, lightheadedness, anxiety, problems in urination and itching. Conversely, side effects caused by effexor but not hydrocodone include diarrhea, gas, stomach pain, heartburn, burping, weight loss, muscle spasms, twitching, hot flashes and excessive sweating.

Potentially Dangerous Effects

Both hydrocodone and venlafaxine are powerful drugs that are known to cause life threatening reactions in extremely rare cases. According to Drugs.com, the rare but dangerous effects that both of these pharmaceuticals can cause often manifest as various conditions of the skin, such as rashes and hives. Other signs of these conditions include swelling of the face, throat, tongue, or lips, and difficulty breathing. Drugs.com recommends contacting emergency services in case a patient taking either one of these drugs experiences any of these side-effects. According to the U.S. National Library of Medicine, venlafaxine can also cause a rare but dangerous condition in which patients consuming the anti-depressant had an increase of suicidal thoughts and mood.


When consumed in excess, one of the effects both hydrocodone and venlafaxine manifest is overdose. This manifests in much the same way in both of these pharmaceuticals. For example, The U.S. National Library of Medicine list dizziness, vomiting, fainting, seizures, muscle pain, hot or cold flashes, increased pupil size, and nausea as possible signs of overdose in both hydrocodone and venlafaxine. Contacting Emergency Services is crucial in the case any of these signs exhibiting in anyone taking either drug, says The U.S. National Library of Medicine.

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