Dehydroepiandrosterone (DHEA) is a hormone that may benefit individuals with adrenal insufficiency, depression or obesity. Some controversial studies also suggest that DHEA may reverse some signs of aging. As DHEA is a hormone, it is contraindicated for a number of different conditions easily affected by hormonal changes. Individuals seeking to use DHEA should consult a physician before taking this supplement.
Heart Problems
Abnormal heart rhythms are a common side effect of DHEA supplementation. DHEA can also increase blood pressure. These side effects may be amplified by alcohol use. Because of the potential side effects of DHEA on the heart and circulatory system, it is advised that people with a history of heart problems or abnormal blood clotting avoid DHEA. MedlinePlus explains DHEA may increase blood coagulation. Individuals using anticoagulants such as Plavix or aspirin to maintain heart health should consult a health professional before using DHEA.
Breast or Ovarian Cancers
DHEA is relatively similar to both male and female sex hormones. Consequently, DHEA supplementation may promote the growth of hormone-sensitive cancers in women, particularly breast and ovarian cancers. According to the Mayo Clinic, women with breast cancer should not use DHEA as DHEA may cause resistance to tamoxifen, a hormone-based drug used to treat many breast cancers.
Prostate Cancer
The American Cancer Society explains that DHEA may increase the chances of developing prostate cancer. Men with prostate cancer or at risk for prostate should consult a health care professional before using DHEA. Men undergoing hormone-based therapies for prostate cancer should avoid DHEA supplements.
Pregnancy
Because of the potential hormonal effects of DHEA, women who are pregnant or breastfeeding should not use DHEA. The American Cancer Society explains that it is generally not recommended that fetuses or newborn infants be exposed to above normal levels of hormones such as DHEA.
Diabetes
DHEA may alter the regulation of blood sugar levels in the body, according to the Memorial Sloan-Kettering Cancer Clinic. It is advised that individuals with diabetes avoid taking DHEA. Likewise, patients using insulin or oral hypoglycemic agents should not use DHEA as it may adversely affect blood sugar levels.
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