According to Genetics Home Reference, a glutathione synthetase deficiency is a disorder that inhibits the production of the glutathione molecule. This tripeptide helps to shield cells from harm by neutralizing dangerous molecules created during energy production. In cystic fibrosis patients, increasing glutathione levels, which are generally reduced due to the disease, can help in avoiding lung damage. A 2008 National Institutes of Health study found that inhaled glutathione for the treatment of asthma, chronic obstructive pulmonary disease, bronchitis, sinusitits and chemical sensitivity rapidly increased the pulmonary glutathione levels, which provided a preventative intervention in the presence of environmental oxidants like pollution. Glutathione requires administration through a nebulizer unit, which uses compressed air or sound vibrations to create a fine mist for inhalation.
Use a dropper or measuring apparatus to obtain the amount of oral glutathione prescribed by a medical professional. The medication often comes in prepackaged plastic ampules with a metered dosage. For example, 10 mL ampules are standard dosing strengths, according to the "British Medical Journal" article "ABC of Poisoning."
Open the nebulizer tube chamber, which is part of the mouthpiece. It is cylindrical and has a mouthpiece as the lid. Turn the mouthpiece to unscrew the lid and place the oral glutathione liquid in the chamber. Screw the lid back on securely.
Connect the tubing to the compressor or sound vibration nebulizer. The tubing is small but usually long and has a fitted end to snugly encase the protruding knob on the nebulizer.
Turn on the nebulizer and wait for a mist to appear, which is the air pushing through the glutathione.
Enclose the lips around the mouthpiece and inhale slowly, taking deep breaths. Depending on the administered glutathione amount, treatment can last anywhere from five to 25 minutes. Continue taking deep breaths for the duration of the treatment. Once the mist ceases, the treatment is complete.
Wash the mouthpiece, chamber and tubing after use to prevent bacteria from growing. Run the items under hot water or in the dishwasher, and allow them to dry before putting them back into the carrying case.
- “Alternative Therapies in Health and Medicine”; Inhaled Glutathione for the Prevention of Air Pollution-Related Health Effects: A Brief Review; Allen J; May 2008
- ClinicalTrials: Efficacy and Safety Study of Inhaled Glutathione in Cystic Fibrosis Patients
- "British Medical Journal"; ABC of Poisoning; Time Meredit, Jane Caisley and Glyn Volans; September 1984
- Genetics Home Reference: Glutathione Synthetase Deficiency