Meloxicam is a nonsteroidal anti-inflammatory drug, or NSAID, used to treat osteoarthritis, rheumatoid arthritis and juvenile rheumatoid arthritis. Tablets come in 7.5 and 15 mg amounts, while an oral suspension comes in 7.5 mg per 5 mL. Meloxicam is also known by its trade name Mobic. Meloxicam is available by prescription only.
Gastrointestinal
Gastrointestinal side effects seen with meloxicam use are similar to those seen with other NSAIDs. NSAIDs increase the risk of bleeding, ulceration, and perforation of the intestines or stomach. Meloxicam doses of 22.5 mg or greater have been associated with more serious gastrointestinal side effects, according to the FDA.gov product insert for meloxicam. Mild gastrointestinal side effects also include nausea and vomiting.
Respiratory
Meloxicam and other NSAIDs can cause respiratory side effects. Anaphylaxis can occur with any medication and represent a severe allergy. Anaphylaxis is a severe, whole-body allergic reaction that can lead to respiratory or breathing difficulties. Some patients have an aspirin-sensitive asthma whereby a severe bronchospasm occurs when they take NSAIDs including meloxicam. Bronchospasm is a condition of muscular constriction of the airway leading to difficulty with breathing.
Dermatologic
Dermatologic side effects of meloxicam include urticaria, or hives, and rashes, according to epocrates.com. Stevens-Johnson syndrome, toxic epidermal necrolysis and exfoliative dermatitis are serious side effects of meloxicam. Stevens-Johnson syndrome is a blistering condition that leads to skin death and shedding, according to MayoClinic.com.
Renal
Patients should be well hydrated when taking meloxicam in order to decrease the risk of kidney damage. Pre-existing kidney disease is a reason to take meloxicam and other NSAIDs with caution. Patients who need to take NSAIDs will usually have closely monitored kidney function.
Cardiovascular
Cardiovascular side effects of meloxicam include myocardial infarction, stroke, hypertension and congestive heart failure. The Mobic product insert found on the FDA's website suggests that the minimal effective dose be taken for the shortest duration possible to reduce the risk of cardiovascular events.
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