The human papillomavirus, or HPV, causes genital warts and infections in the genitourinary tracts and throats of males and females. HPV is associated with cervical cancer, the second most common cause of female cancer deaths, as well as cancer of the vagina and vulva. Since Merck developed an HPV vaccine called Gardasil, adolescents and adults can opt for a series of three injections that offer long-term protection against common strains of HPV. However, Gardasil is associated with some potential problems.
Injection Site Reactions
Gardasil causes redness at the site of the injection in eight out of 10 people, according to Medline Plus. Some individuals report swelling, pain, bruising or itching at the site of the injection.
Response to a Shot
Like other injected vaccines, Gardasil can cause nausea, vomiting, dizziness, fainting and seizure-like movements immediately after it's given. These reactions are generally short-lived, disappearing after the person has a chance to lie down with his feet elevated. It's a good idea to stay seated in the health care provider's office for 15 minutes after receiving the vaccine to avoid injury from a fall.
Headache
Headache is the most commonly reported problem after Gardasil administration among boys, girls, men and women, according to Merck.
Fever
One out of every 10 people develops a fever of less than 100 degrees after receiving a Gardasil injection--and one in 65 develop a moderate fever, ranging from 100 to 102 degrees. Fever doesn't indicate an HPV infection from the vaccine, which is made with inactivated, or killed, viruses.
Anaphylaxis
Merck's product literature describes the possibility of a life-threatening allergic reaction called anaphylaxis following a Gardasil shot. Because the vaccine is made with yeast, people with a severe yeast allergy shouldn't get Gardasil injections. It's important seek medical attention right away for any hives, itching, facial swelling or breathing problems.
Delayed Problems
Merck reports that Gardasil has been associated with more serious problems up to several months after an injection. Therefore, persistent fatigue, joint pain, chest pain, muscle aches, chills, stomach pain, bruising or bleeding should be reported to your health care provider.


