Pancreatin, sold under the brand name Hi-Vegi-Lip or Pancreatin 4X, is a digestive enzyme supplement used to replace digestive enzymes when the pancreas is not producing enough. Providence Health & Services describes pancreatin as an important supplement to aid in the digestion of fats, proteins and sugars in individuals with medical conditions such as diabetes and pancreatitis. There are, however, several contraindications for pancreatin.
Elevated Amylase Levels
Amylase is an enzyme produced in the body that aids in the digestion of carbohydrates. Pancreatin should not be taken by individuals with elevated amylase levels in the blood or urine. MedlinePlus states that individuals can experience elevated amylase levels if they have any of the following conditions: acute pancreatitis; cancer of the pancreas, ovaries or lungs; cholecystitis; a gallbladder attack; salivary gland infections; intestinal obstruction; macroamylasemia; a perforated ulcer; a tubal pregnancy; or viral gastroenteritis.
Taking Pancrelipase or Miglitol
Pancrelipase and miglitol are enzymes used to treat a number of digestive disorders but are contraindicated for use with pancreatin. Providence Health and Services suggests that if an individual is already taking an enzyme supplement, he should not take pancreatin.
Pancrelipase's brand names include Cotazym, Creon 5, Kutrase, Lipram, Panokase and Ultrase. It is usually prescribed to improve digestion in those who have a condition affecting the pancreas.
Miglitol is sold under the brand name Glyset and is often prescribed for diabetics. According to Monthly Prescribing Reference, however, pancreatin can cancel out the glucose-lowering effects of miglitol and should not be taken at the same time.
Pregnant or Nursing
Providence Health & Services cautions that pancreatin might be harmful to an unborn baby and suggests that patients who are pregnant or plan to become pregnant inform their doctor before taking the medication.
It has not been determined if pancreatin passes into breast milk or if it can harm a nursing baby. Therefore, nursing mothers should consult with their doctor before taking pancreatin.
