Apcalis is the generic form of Cialis, also known as tadalafil, and is used to treat erectile dysfunction. Apcalis acts on enzymes in blood vessel walls causing vasodilation and increased blood flow into the penis. It belongs to the drug class of phosphodiesterase type 5 inhibitors, which also includes sildenafil and vardenafil.
Headache
The most commonly reported side effect of Cialis in clinical trial studies was headache. The National Library of Medicine reports on its website, DailyMed, that headaches occurred in up to 15 percent of men taking Cialis.
Heartburn
Reported on DailyMed, 3 to 5 percent of men who took Cialis in clinical trial studies experienced heartburn or indigestion.
Common Cold
In clinical trial studies reviewed on DailyMed, the incidence of nasal congestion rose to 4 percent while the incidence of common colds increased by up to 6 percent in men who took Cialis.
Back Pain
Reported on DailyMed, back pain was observed in 3 to 6 percent of men who took Cialis. In most cases, back pain was mild to moderate and resolved in 48 hours without medical treatment.
Vision Impairment
Reported on DailyMed, Cialis caused impairment in color discrimination in less than 0.1 percent of men in clinical trial studies. A few post-marketing reports state that Cialis is associated with vision loss; however, these reports also indicated that men with vision loss displayed other risk factors for cardiovascular disease. A review published in "Drug Safety" concluded that there is no evidence that Cialis causes adverse effects on vision.
Hearing Loss
Some men have reported hearing impairment after taking Cialis or other phosphodiesterase type 5 inhibitors. A study in the May 2010 issue of the "Archives of Otolaryngology--Head and Neck Surgery" states that after evaluating self-reports of hearing impairment the association was only observed in those who took Viagra and not Cialis.
Contraindications
Phosphodiesterase type 5 inhibitors stimulate the same enzymatic pathway as nitrates and they will intensify the blood pressure lowering activity of these drugs. Also, if used in combination with other antihypertensive medications, such as alpha-blockers, the effects on blood vessel dilation may be additive. Taking Cialis alone does not significantly affect blood pressure or heart rate.
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