Phosphatidylserine is a kind of fat found in cells. It was initially isolated and identified in 1942, according to the website Healthy Source. MayoClinic.com says that originally it was originally taken from bovine brain cells until the incidence of mad cow disease caused concerns. Manufacturers then began to derive phosphatidylserine from soy and cabbage. There is some clinical evidence that the substance helps reduce anxiety when used as a supplement.
Studies
MayoClinic.com warns that most studies have focused on cow-derived phosphatidylserine, and it is unclear if the plant-derived version will result in the same benefits. Healthy Source indicates that there have been at least 60 clinical trials and 3,000 research papers on the benefits and function of phosphatidylserine. Life Extension Magazine cites a study conducted by the University of Wales of a group of adults with high stress scores. They received 300mg of phosphatidylserine for a month and were assigned a task expected to increase anxiety at the end of that time. The university recorded changes in heart rate, as well as self-reported anxiety. The results showed all subjects experienced lower anxiety levels.
Function
Phosphatidylserine works by facilitating the messages transmitted between brain cells through the increase of membrane receptor sites, according to Healthy Source. The website NutritionalReviews.org reports that phosphatidylserine works on the human body in three ways: by stimulating overall brain metabolism and by regenerating and restoring damaged nerve networks. It spurs the production and release of dopamine, a neurotransmitter that affects mood and the perception of pleasure and pain. Life Extension Magazine says that it also functions to decrease cortisol levels, a stress-related hormone.
Dosage
NutritionalReviews.org recommends 600mg of phosphatidylserine per day for mood-related problems and disorders. The U.S. Food and Drug Administration notes that phosphatidylserine is present in the average diet at levels from 75 to 184mg milligrams a day.
Effects
According to NutrionalReviews.org, high cortisol levels over an extended period of time can result in several health complications, including high blood pressure, heart disease, immune deficiencies and diabetes. Phosphatidylserine has the effect of alleviating some of these risks by lowering cortisol and reducing anxiety. Phosphatidylserine also improves memory and relieves depression.
Side Effects
NutrionalReviews.org reports no negative side effects from phosphatidylserine supplements. (Reference 3) The U.S. Food and Drug Administration also deems soy- and cabbage-derived phosphatidylserine to be safe with no notable side effects from doses up to 600mg a day for three months.
