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Plasil Side Effects

author image Jamie Simpson
Jamie Simpson is a researcher and journalist based in Indianapolis with more than 10 years of professional writing experience. She earned her B.S. in animal science from Purdue University and her Master of Public Affairs in public management from Indiana University. Simpson also works as a massage therapist and equine sports massage therapist.
Plasil Side Effects
Plasil is commonly prescribed to diabetic patients experiencing digestive problems. Photo Credit Medioimages/Photodisc/Photodisc/Getty Images


Plasil is the international trade name for medications based on the generic compound metoclopramide, which is marketed in the United States under the brand names Reglan and Metozolv ODT, according to MayoClinic.com. The medication is targeted at diabetes patients who are having problems with their digestive activities and individuals who have heartburn caused by gastroesophageal reflux disease. Plasil users should be aware of its side effects.

Drowsiness and Fatigue

A commonly reported side effect of Plasil is drowsiness and fatigue, according to MedlinePlus. Symptoms of drowsiness and fatigue range in severity. Mild cases are not considered to be a serious side effect of Plasil use, but extreme drowsiness or fatigue may be a sign of an overdose.


MayoClinic.com notes that diarrhea is a commonly reported but not serious side effect of taking Plasil. As the medication is partly designed to aid in digestive processes, this side effect can be considered a natural part of treatment initially. If the diarrhea does not go away over time, MedlinePlus recommends reaching out to a doctor, especially if there is a history of bowel irritation or intestinal disorder to consider.


Plasil's main ingredient, metoclopramide, has been found to be addictive. Drugs.com notes that it may be hard to quit taking the medication due to the potential for withdrawal effects. Patients who feel they are addicted to the medication should consult their doctors for treatment.

Tardive Dyskinesia

A rare and unusual side effect of Plasis is tardive dyskinesia. MedlinePlus notes that tardive dyskinesia is caused by the metoclopramide present in the Plasil, and the longer the metoclopramide is consumed the greater the risk of developing tardive dyskinesia.

The symptoms of tardive dyskinesia are muscle ticks and contractions in the face that patients will be unable to control, such as lip smacking, puckering of the mouth, sticking out the tongue and blinking. MedlinePlus notes that elderly and female patients are more likely to develop tardive dyskinesia than other users. To avoid this side effect, Drugs.com notes that it is not recommended to take the medication for more than 12 weeks at a time.

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