According to the Lupus Foundation of America, approximately two-thirds of lupus sufferers develop some form of skin disease that causes rashes or sores, most often located on the face, ears, legs, arms or neck. These skin diseases can worsen due to exposure to ultraviolet light. Skin irritation from these diseases are treated in a variety of ways, including steroids, thalidomide and a class of drugs called topical immuno-modulators.
Steroids
The Lupus Foundation America reveals that most common treatments for lupus-related skin irritation involve ointments like steroid cream or gel, as well as liquid steroids injected into lesions. Dermnetnz.org indicates mild steroid creams and gels find use for less severe rashes; however, stronger options applied accurately to graver lesions prove effective if applied once or twice daily. Oral steroids are also used to combat skin irritation from lupus.
Thalidomide
Thalidomide finds use as an effective treatment for lupus skin irritation, as well as other severe dermatological conditions, according to Dermnetnz.org. This drug reduces the levels of cytokine tumor necrosis factor-alpha, or TNF-alpha, in the body. TNF-alpha causes inflammatory reactions. Because it may result in severe birth defects, thalidomide is strictly monitored when prescribed. Researchers at the University of Pennsylvania find the drug can ease skin irritation in approximately 90 percent of patients, while 15 to 20 percent of patients achieve remission of symptoms.
Topical Immuno-Modulators
Topical immuno-modulators treat severe skin conditions, like those caused by lupus, by suppressing immune system activity. The benefit of using these drugs involves the lack of side effects often found in steroids, according to the Lupus Foundation of America. Options like pimecrolimus cream and tacrolimus ointment do not cause skin thinning or adrenal suppression, which can be useful for treating skin irritation on sensitive, thin-skinned areas. Side effects include initial burning, feeling of warmth or itching.
