Namenda, manufactured by Forest Pharmaceuticals, is a prescription medication indicated in the treatment of Alzheimer's disease. Through a distinct method of action within the brain, Namenda works to help manage symptoms associated with Alzheimer's.
Memantine Hydrochloride
Namenda is the trade name for the drug memantine HCl, which is available as a tablet in 5-mg and 10-mg strengths. Memantine is classified as an NMDA antagonist, reports the National Institutes of Health. NMDA, which stands for N-methyl-D-aspartate, is a type of receptor within the brain responsible for the regulation of glutamate--a chemical associated with learning and memory, according to Forest Pharmaceuticals.
Method of Action
When a person takes a dose of Namenda, the medication acts on the central nervous system, binding to the NMDA receptors and blocking the brain's NMDA glutamate pathways. This can prevent damage to brain neurons associated with excess glutamate release, according to the National Pharmacy Benefits Management's drug monograph for memantine HCl.
Dosage Titration
In order for Namenda to work properly, a specific dosage titration is indicated. Most people prescribed to Namenda for Alzheimer's disease must start with a "titration pack" of the medication--a gradual upward tapering of dose over the course of four weeks. This titration allows the person's body and central nervous system to slowly get used to the medication, and generally increases from 5mg to the therapeutic dose of 20mg daily over the four weeks.
Effects
Namenda's effects as an NMDA antagonist can work to improve the lives of people suffering from Alzheimer's disease. By inhibiting excess glutamate, Namenda functions to decrease abnormal activity in the brain, allowing a person living with Alzheimer's to experience more clarity of thought and more easily perform day-to-day activities.
Considerations
Although Namenda purportedly works to help ameliorate the symptoms of Alzheimer's disease, the medication is not a cure. Additionally, it doesn't stop the progressive nature of Alzheimer's disease. If you or someone you know is considering taking Namenda, talk to your doctor about the medication's potential benefits, as well as its possible side effects. These include dizziness, constipation, drowsiness and vomiting.
