Seroquel is a brand name for the antipsychotic medication quetiapine fumerate, which is approved for the treatment of schizophrenia and specific components of bipolar disorder. Individuals who take Seroquel have an increased risk of developing symptoms of hyperglycemia, an elevated blood glucose level associated with diabetes. Individuals who are obese or have a family history of diabetes should have a fasting blood glucose test before taking Seroquel and then periodically while they're on the medication, according to DailyMed, a National Library of Medicine website. It's important to report any symptoms of hyperglycemia to the doctor right away.
The 3 P's
Early signs and symptoms of the hyperglycemia associated with diabetes include the 3 P's: polydipsia, polyuria and polydipsia, notes RxList.com. Polydipsia, or excessive thirst, contributes to polyuria, or excessive urination, but people with high blood glucose levels also urinate more than expected for the amount of fluids they've ingested. Polyphagia, or excessive hunger, causes people to ingest large amounts of food that are converted to glucose in the body, further increasing the blood glucose level.
Weakness and Fatigue
When blood glucose levels are high, people feel weak and tired without really knowing why, according to DailyMed. While it can be difficult to distinguish weakness and fatigue associated with diabetes from some of the adverse effects of the Seroquel, it's important to report continuing problems to the prescribing physician.
Nausea
High blood glucose levels, combined with too much food and drink, can make people feel nauseated and bloated. Since nausea and vomiting are also side effects of Seroquel, it's important to discuss these issues with the doctor.
Diabetic Ketoacidosis
If high blood glucose levels continue over time, byproducts called ketones may build up and lead to diabetic ketoacidosis, or DKA. Individuals with DKA may breathe rapidly and deeply, exhaling fruity-smelling breath. Other symptoms of DKA include flushed face, skin that's dry and pale, nausea and vomiting, abdominal pain, and mental changes such as confusion and stupor, according to MedlinePlus. Untreated DKA may progress to coma and even death in individuals taking Seroquel.
Hyperosmolar Coma
If diabetic ketoacidosis continues untreated, people on Seroquel may go into a hyperosmolar coma with loss of consciousness, convulsions and sometimes weakness, loss of sensation, and dysfunctional movement of the muscles, according to RxList.com. A hyperosmolar coma is a medical emergency, with treatment aimed at lowering blood glucose and reversing dehydration, explains MedlinePlus.
