Effexor, the brand name for the generic venlafaxine, is an antidepressant medication and a chemically synthesized neurotransmitter messaging system. This system allows the brain to send messages to nerve cells to decrease the symptoms of depression. Effexor is a serotonin-norepinephrine reuptake inhibitor or SNRI, according to the eMEDTV website. The site says Effexor improves long-term depression and relapse prevention by assisting the body in balancing serotonin and norepinephrine levels.
Identification
The Food and Drug Administration identifies Effexor as venlafaxine hydrochloride that is an antidepressant for oral use. Effexor is a white or off-white powder that's soluble in water. Its inactive ingredients include cellulose, iron oxides, lactose, magnesium stearate and sodium starch glycolate, according to the FDA. Effexor is metabolized in the liver and is not affected when taken with food. As an SNRI, Effexor balances serotonin and norepinephrine levels in the brain. It's different from Effexor ER, a product that has additional uses and a different absorption timetable in the body.
Effects
The Merck Manual indicates that Effexor is effective in the treatment of major depression, generalized anxiety disorder, social anxiety disorder, social phobia and panic disorder. Merck says this antidepressant is currently under investigation and trial research for use with obsessive-compulsive disorder, hot flashes, neuropathic pain, attention-deficit/hyperactivity disorder and post-traumatic stress disorder. The FDA reports that some clients have increased hypertension symptoms resulting from Effexor, as well as a condition related to glaucoma. In addition, the FDA notes that in some cases, clients taking Effexor have increased cholesterol levels.
Dosages
The Merck Manual recommends dosages of 75mg, prescribed in two or three divided doses throughout the day for treating depression symptoms. The manual indicates that dosages can be increased up to 375mg per day in four-day increments until the desired dosage is achieved. The manual lists dosage recommendations for conditions still in trial use, referred to as unlabeled use. The conditions include neuropathic pain-dosages of 75mg to 225mg and hot flashes dosages of 37mg to 57mg per day. Merck notes that Effexor can be prescribed for attention-deficit disorder at dosages of 18mg to 75mg.
Considerations
The Physician Desk Reference reports that Effexor should not be prescribed for children or adolescents. The PDR source indicates that antidepressants can increase suicidal behavior in children and adolescents. All clients under treatment for depression should be supervised for changes in behavior while on Effexor as well as any antidepressant medication. In addition, clients and their families should notify their doctor immediately if any new symptoms develop, or if their loved one's symptoms increase. The Physician Desk Reference reminds caregivers to be aware of behavior changes such as anxiety, hostility, insomnia, restlessness, impulsive or dangerous behavior, and thoughts about suicide or dying.
Expert Insight
According to the Merck Manual, dental patients receiving anesthesia and taking Effexor should be prescribed a vasoconstriction medication. During dental procedures, Merck notes, the client's vital signs should be monitored because venlafaxine produces a lasting increase in diastolic blood pressure and heart rate.
