Deptran is a dibenzoxepin tricyclic compound that is prescribed for the treatment of depression. It is called tricyclic because its chemical structure contains three rings. Deptran's mechanism of action is unknown. Deptran is available as a capsule and also as a mint-flavored oral concentrate in liquid.
Systemic Side Effects
According to a 2004 study by Kenneth Wilson and Pat Mottram published in the "International Journal of Geriatric Psychiatry," gastrointestinal side effects are experienced at a higher rate in those taking classical tricyclic antidepressants, compared to those taking selective serotonin reuptake inhibitors. They are also associated with significantly higher withdrawal rates. Some of these side effects include constipation and nausea. Other side effects may involve difficulty or frequent urination, dry mouth and excessive sweating.
Neurological Effects
There are some neurological side effects associated with this medication. These may include drowsiness, weakness, tiredness, nightmares or blurred vision. The drowsiness tends to decrease and disappear over the course of treatment. While taking this medicine, skin may be more sensitive to sunlight. Changes in sex drive or ability or changes in appetite or weight are other potential side effects.
Muscle or Gait Problems
More serious side effects of Deptran use include muscle or gait problems. Muscle problems may include back, neck and jaw muscle spasms. Gait issues related to Deptran use are characterized by a shuffling walk or uncontrollable shaking in a body part. The heart may also be affected, in the form of an irregular heartbeat. These symptoms should be reported to a physician.
References
- Pfizer: Deptran Prescribing Information
- "International Journal of Geriatric Psychiatry"; A Comparison of Side Effects of Selective Serotonin Reuptake Inhibitors and Tricyclic Antidepressants in Older Depressed Patients: A Meta-analysis; Kenneth Wilson and Pat Mottram; August 2004
Member Comments