AndroGel is a topical testosterone product that is available in transdermal patch form and as a topical gel. This product is used in males to replace hormones when the individual is suffering from a deficiency or absence of testosterone production. It is recommended for use in two conditions, primary hypogonadism and hypogonadotropic hypogonadism.
Primary Hypogonadism
Primary hypogonadism, also called primary testicular failure, occurs when the testes stop producing testosterone, according to MayoClinic.com. There are several causes for this condition. One is having too much iron in the blood, also known as hemochromatosis. Direct injury of the testicles is another cause; because they are anatomically on the outside of the body, they are vulnerable to injury. Cancer treatment with chemotherapy or radiation can also interfere with normal sperm and testosterone production. This side effect is usually temporary, but in some cases, it may be permanent. Finally, a normal part of male aging is decreased testosterone production.
Hypogonadotropic Hypogonadism
Like primary hypogonadism, hypogonadotropic hypogonadism involves decreased or no production of testosterone by the testes. This condition is considered secondary hypogonadism, which means that the decreased hormone production is a result of dysfunction in brain areas that control testosterone production, such as the hypothalamus or pituitary, explains MedlinePlus. This condition may be a result of either a tumor of the pituitary gland or an abnormal development of the hypothalamus. Ordinarily, the hypothalamus releases gonadotropin-releasing hormone, prompting the pituitary gland to release luteinizing hormone and follicle-stimulating hormone. These two hormones signal the testes to release testosterone, which is essential for normal development. Typical sexual maturity can be prevented if this chain of events is disrupted. Symptoms may include loss of the sense of smell, absence of secondary sex characteristics such as pubic hair, underdeveloped testicles or lack of development at puberty.
Important Warning
Women and children should not come into contact with AndroGel. It should only be applied to areas that would be covered by a short-sleeved t-shirt. After contact with the medication, the skin should be washed before it comes into contact with anyone else's skin, and hands should be washed immediately after applying the gel. There have been reports of signs of puberty in very young children who were accidentally exposed to AndroGel, cautions Solvay Pharmaceuticals, the medication's manufacturer. In children, symptoms of AndroGel exposure may include aggressive behavior, enlarged penis or clitoris, or early development of pubic hair. Symptoms in women include increased acne and changes in body hair.
